Generally speaking, the regular R GUI has been easier to use for blind/low-vision users (though RStudio has been working on accessibility features, e.g. the link from @williaml).
A. Jonathan R. Godfrey (who is blind, himself) has done quite a bit of analysis on R vs. other statistical software for blind users, and written the BrailleR package (as well as a book on using it), all of which might be helpful to you.
I should note, however, that Excel wasn't part of the comparative paper I'm thinking of.
He also authored and maintains a page on statistical software and blind users here: https://r-resources.massey.ac.nz/StatSoftware/