Thanks for the reply. I know that it is difficult to understand what's happening in this case. I was "hoping" that someone else was observing the same behaviour, which could aid to more easily pinpoint its cause.
For now, I can just say that I tend to use CTRL-SHIFT-L a lot for automatically saving all changed files and update everithing before testing when I'm working on a package. Also, the other devtools shortcuts seem unaffected (e.g., CTRL-SHIFT-B continues to work). I'll see if I can mangae to pinpoint the problem a bit more.