I have two versions of the R startup script running in OS X Catalina. One is R.framework, pointing at the usual 3.6.1 framework build, the other is R.unix, pointing at R-Devel (4.0.0) in /usr/local. Both run fine in Terminal.app. The Rstudio IDE runs fine if I link the R script to the framework build, but if I link R to R.unix the IDE says it cannot connect to 127.0.0.1.
You might try running a diagnostics report and see if anything helpful is reported.
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