Fatal Error: ERROR r error 4 (R code execution error)

I've been using RStudio (not sure version, maybe 1.3) for months. When launching RStudio today, I am getting the following Error and Rstudio window shows the menu items, but no response at all when clink on it. What it happens and what is the solution?

Fatal error: Error r error 4 (R code execution error) [errormsg=Error in file(filename,"r",encoding=encoding): cnanot open the connection];OCCURED AT: class rstudio::core::Error_cdecl::r::exec::evaluateString(const class,std::basic_string<char,struct std::char_traints,class std::allocator &, struct SEXPREC *,class

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