I hope you love LaTeX, too! Rmarkdown can output slides using either ioslides or beamer (a LaTeX packages). This SO thread has managed to torture the beamer.sty to be Tuftesque. Since you can insert LaTeX into your doc, it's possible in theory to achieve your desire.
Alternatively, you might just just the provided template or tint (this is not Tufte) with lots of page breaks. Classic Adobe has a slide mode, but I'm not sure where to look for it now.
Happy Trails to you.