paid / Oxford, United Kingdom / full-time
MiroBio is developing novel therapeutic molecules to treat immune-mediated disease and is looking for a talented and motivated bioinformatician to contribute to our research. The post holders will be responsible for processing raw data from both in-house and public sources; performing statistical analyses and generating visualisations to uncover novel biological insights; and contributing to wider understanding of results amongst colleagues. This will involve applying existing pipelines and analytical methods, alongside the development of new informatic tools. A core part of the bioinformatics group, the role will provide key contributions across the breadth of MiroBio’s research programmes.
We are looking for candidates who are highly-technically skilled and are excited to help us:
Create interactive tools to facilitate data visualisation and accessibility across the organisation.
Carry out high-quality, robust, analyses of ‘omic’ datasets to generate biological insights contributing to ongoing experimental research.
Develop analytical capacity for cutting edge biological profiling techniques, such as single-cell transcriptomics.
MiroBio is on a mission to treat a range of autoimmune and inflammatory disorders. The company was founded by leading immunologists at the University of Oxford who have spent over 15 years focussed on understanding the mechanisms which underlie T-cell signalling.
The technology is based on an IP portfolio of novel therapeutics with the ability to activate inhibitory co-receptors on the surface of immune cells. With a deep mechanistic understanding, MiroBio’s platform further optimises these molecules to create immunomodulatory therapies which have shown remarkable efficacy in preclinical animal models of disease. MiroBio is building a team and platform with strong biological expertise to address significant unmet medical needs in patients with chronic inflammatory diseases.
MiroBio is a spin-out from the Oxford University with an initial investment of £27M from Oxford Sciences Innovation, Samsara Biocapital, SR One and Advent Life Sciences. The company is based on the Oxford Science Park in a hub of exciting start-up companies and bioscience innovators.
- Statistical analysis of both in-house and public datasets to generate biological insights.
- Processing of ‘omics’ data, such as RNA-Seq, from raw sequencing files using established workflow tools.
- Creation of interactive interfaces for data visualisation to increase data accessibility.
- Contribute to planning and execution of NGS related projects across experimental programmes.
SPECIFIC SKILLS AND EXPERIENCE
- In-depth practical experience of analysing biological data and generating summary reports.
- Experience developing interaction data visualisations (esp. using Shiny).
- Examples of previous work analysing large omics datasets, ideally single-cell transcriptomics, to derive biological insights in disease.
- In depth practical experience working on remote, Unix-based, compute clusters.
- Experience developing and/or using bioinformatics pipelines within an established workflow manager (Snakemake, NextFlow etc.).
- Examples of work demonstrating strong coding skills in R/Python (ideally both).
- Exceptional organizational skills with attention to detail and a logical approach to data management.
- Well-grounded knowledge of statistics, with a particular focus on the challenges of bioinformatics analyses.
- Experience with relational database design and/or use (MySQL etc.).
- Examples of bioinformatics pipelines/package developed and released for wide scale use.
- Examples of work in scientific publications.
- PhD in bioinformatics; or Masters/bachelor’s degree plus equivalent industry experience can also be considered.
- Hands-on grafter with a practical mindset who likes to get-things-done
- Flexible problem-solver with trouble-shooting mind-set and a desire to overcome challenges
- Focussed executor, who delivers work on time, is pro-active and driven
- Straightforward communicator, with a willingness to be open, honest, admit mistakes and listens to others
- Motivational team member, keen to work with others and foster a great company culture
WHAT’S IN IT FOR YOU?
Challenge: Early stage biotech is an exciting and agile environment to work in, we have a lot to get done and it will be all-hands-on-deck.
Training: You’ll be working directly alongside experienced scientists providing technical training for a range of skills
Culture: As part of a small team, you will play a major role in setting team dynamics and company culture
Exposure: You’ll be working closely with the Senior management team, and also be a part of multi-disciplinary project teams, learning drug discovery and development, business and commercial skills
Purpose: Developing novel therapies for patients with high unmet medical need
Ownership: All team members are incentivised with equity in the company
WORK ENVIRONMENT AND LOCATION
This is a small (~20 FTE) and growing, fast paced organization. The desire and ability to be productive and successful in an intense work environment are critical.
The laboratories are in Oxford, at the Oxford Science Park.
- Read, write and speak fluent English
- Right to work in the UK
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