I already had new XQuartz. I also removed all .RData files.
I worked with CNN lately and I guess it was long time to load data.
Finally, I choose 'Keep waiting" and it opened now! What a relief
Nothing can be frustrating then be out of my favorit R Studio tool !
Thank you All are good now. Just need to reinstall all my packages!
It's a really good idea to save your workspace and your source code explicitly rather than saving the workspace when you exit and restoring it when you load.