I am working at a major research institution in the US and couldn’t find a satisfying answer to my question about my research methodology. I want to compare certain type of treatment (hereinafter referred to as “BUBBLE”) with the risk of developing a rash. This treatment, BUBBLE, is used to treat depression in kiddos and is applied to the head. The individuals need to visit the clinic twice a week. However, based on their response, we can increase or decrease the frequency of their visits. In addition, their visits were disrupted due to the COVID pandemic in early 2020.
I have a list of 2 groups of patients: Patients who received BUBBLE and developed rash and patients who received BUBBLE but did not develop a rash.
I have the following information available:
Their index BUBBLE treatment date
List of dates for each of their visits for BUBBLE.
The dates when they first noticed rash
Concomitant medications right before they developed rash
-Depression scores here and there during their treatment course
-Comorbid medical conditions
-Comorbid psychiatric conditions
- Photos of rash
We have several questions:
1- Does BUBBLE increase the risk of developing a rash?
2- Does the frequency or number of BUBBLE treatments increase the risk of rash?
3- Is there a subgroup of patients who are more likely to develop a rash with BUBBLE?
What would be a good methodology in this particular case?