dbConnect on oracle works in R but fails in RStudio

I am attempting to connect to Oracle Database using the odbc package on OSX High Sierra. I installed version 19-3 of the instantclient and use unixodbc 2.3.7. Following this link, I turned all the run-paths into absolute paths and managed to make it work in the terminal via isql and when calling R at the command line. However, in RStudio I keep getting the following error:

Error: nanodbc/nanodbc.cpp:983: 00000: [unixODBC][Driver Manager]Driver's SQLAllocHandle on SQL_HANDLE_HENV failed

I use the exact same command in R and Rstudio:

con <- DBI::dbConnect(odbc::odbc(), driver = "OracleODBCDriver", ...)

This error persists. In this article, I read that this error may occur if the ORACLE_HOME environment variable is not set. However, mine is set and points to the same directory in the terminal and in RStudio - namely /opt/oracle/instantclient_19_3.

Any ideas would be highly appreciated - I'm really desperate.

PS: One thing catching my eye is the output of otool -l libsqora.dylib.19.1. While in many examples the path to LC_RPATH is @executable_path/../../oracle/lib, mine is /ade/b/3727680341/oracle/lib/.

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